Journal: BMC Biology
Article Title: Spatial and temporal heterogeneity in the lineage progression of fine oligodendrocyte subtypes
doi: 10.1186/s12915-022-01325-z
Figure Lengend Snippet: Nearest neighbor (NN) analysis for oligodendrocytes in P20 and P60 tissue sections. a For each cell, a region is plotted (tiles in the background), where all points of the region are closer to that cell than to any other (Voronoi tessellation). Each cell is a node in the graph and the edges connect the neighboring cells (Delaunay triangulation). A zoom-in is shown for the WM region. The main scale bar is 500 μm, and the zoom-in scale bar is 250 μm. b Heatmaps of the nearest neighbor likelihood (significant neighboring preferences highlighted by red boxes) and barplot of average distances to most prevalent NN for P20 CTX (top) and CC (bottom) ( n = 6 P20 tissue sections). c Same as ( b) for P60 CTX and CC ( n = 6 P60 tissue sections). d Same as ( a) for the spinal cord. The main scale bar is 100 μm, and the zoom-in scale bar is 50 μm. e Same as ( b) for spinal cord P20 GM and WM ( n = 6 P20 tissue sections). f Same as ( e) for spinal cord P60 GM and WM ( n = 6 P60 tissue sections)
Article Snippet: Nearest neighbor analysis was performed by first partitioning the cell maps into regions using the MATLAB function voronoi.
Techniques: